Pathology Associates Of Lexington, P.A.

Columnar Cell Lesion

The "flat" in FEA refers to overall sillohuette of the dilated TDLUs, NOT to the shape of the lining epithelial cells. ACTIONS: (1) when detected in core biopsies: excision of FEA, ADH, OR CIS target area is indicated because 25% or greater chance of closely associated worse lesion; (2) when detected in excision specimen: be sure all non-fatty tissue submitted and also maybe step-cut blocks to rule out any closely associated worse lesion. ADH, ALH, CISs, and invasive cancers (especially tubular ca. or lobular neoplasia) are the "worse" lesions. ADH is not just minimal atypia; it is almost-CIS-like...not completely qualifying as CIS.

(for more detail, check "epithelial lesions" & scroll to "hyperplasia", here).

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Ref: After Schnitt S.J., 38^th Annual McKee Cytology Seminar and Pratt Thomas Symposium in Surgical Pathology, MUSC, Charleston, SC, 26 April 2005.

[Posted 16 August 2005; latest update 8 June 2006]