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| Lactate
Dehydrogenase test, blood |
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Lactate Dehydrogenase, Serum
This is one of the serum enzymes commonly present in general laboratory
chemistry panels or profiles.
Causes of DECREASED Values/Levels
- medications (analytical artifact vs. real)
- aging
- hemodialysis
Causes of Increased Values/Levels
- hemolysis within a mishandled or too old specimen
- hemolytic anemia
- situations of "ineffective erythropoiesis" (premature
cell death of bone marrow red blood cell precursors (unless combined
with other nutritional deficiencies, especially iron deficiency):
- megaloblastic anemia (B12 or Folate deficiency)
- myelodysplastic syndromes (MDS)
- muscle injury
- hypothyroidism
- myocardial infarction
- pulmonary infarction (released from RBC's)
- SARS with blood lymphopenia
- liver injury: ischemic factors elevate LDH, as with heart failure, other vascular ischemic etiologies, and acetaminophen.
- renal infarction
- chronic alcoholism
- mononucleosis
- leukemia or lymphoma: the "international index" [Shipp
criteria
] for lymphoma staging utilizes LDH (normal vs. elevated) as
one of the criteria
- excessive cellular destruction situations (i.e. chemotherapy
or extensive malignancies)
- acute pancreatitis
- collagen diseases
- strenuous exercise activity
- medications (analytical artifact vs. real)
Test Synonyms
Other names for this exact or approximate agent are:
- LDH, serum
- Lactic Dehydrogenase, serum
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