Pathology Associates Of Lexington, P.A.
Pathology Associates Of Lexington, P.A.
Pathology Associates Of Lexington, P.A.
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        Brunt system, grading/staging NASH
      
Necroinflammatory Activity Grade
  grade 1, mild grade 2, mod grade 3, severe
steatosis up to 66% of Bx any panacinar
balooned hep cells occasional cell more cells, zone 3 obvious &disarray
intralob. pmns scattered & rare more more & /w the balooned cells
intralob lymphs +/- present present;+/- mild
portal chronic cells no to mild portal and acinar mild/mod & not marked
Fibrosis Stage
  stage 1 stage 2 stage 3 stage 4
perisinusoidal &/or pericellular focally or extensively present focally or extensively present, with focally or extensively present, with focally or extensively present, with
periportal   focally or extensively present focally or extensively present, with focally or extensively present, with
bridging     focally or extensively present focally or extensively present, with
cirrhosis       present

References:

  1.  Brunt EM, et. al., Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging the Histological Lesions, Am. J. Gastroent. 94(9):2467-2474, September 1999.

 

(posted 2 April 2005)

 
 
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