CHECK OUT American Society of Hematology Image Bank, here at their website.

• Non-lymphoid tissue based:
  1. primary intravascular lymphoma...IVL (most are B cell):
  2. primary cutaneous (systemic but favors skin) lymphoma:
     • Mycosis fungoides (T cell) in various forms⁴:
       1. subtle scaly macules & patches (guttate parapsoriasis; digitate dermatosis).
       2. single plaque (Woringer-Kolopp disease; pagetoid reticulosis).
       3. erythroderma (Sezary syndrome).
       4. pendulous masses (granulomatous slck skin).
  3. primary body cavity lymphoma (primary effusion lymphoma...PEL [most are B cell]).
  4. primary bone marrow presentation [LMC-01-8371].
  5. primary soft-tissue lymphoma:
     • Rosai-Dorfman Disease (sinus histiocytosis with massive lymphadenopathy [SHML]) [S-00-2994].
• Lymphoid tissue based (originating in sites of natural or acquired lymphoid tissue):
  1. mucosa associated lymphoid tissue...MALT...lymphoma:
     • nasopharyngeal.
     • intestinal (to be differentiated from benign lymphoid hyperplasia of the GI tract² [S-02-1710]).
     • bronchial (BALT) [? FA-06-46?].
  2. thymic/mediastinal:
  3. splenic:
• Lymph node based (originating in nodes): (see your copy of 2001 WHO book).
• Pattern notes:
  • diffuse small cell:
    • monotonous: first think of LP Hodgkin lymphoma; then mantel cell (MCL)
    • mottled: first think of nodular LP Hodgkin lymphoma; then marginal zone (MZL)
  • large cell:
• Plasma cell & MGUS workups: (In diagnosis and staging, everyone should remember that the "multiple" of mutiple myeloma indicates the focality of cell-rich to cell-poor areas in marrow...false negative biopsies based on sampling error and "stable " vs. "progressing" errors if a marrow sample is all that is considered. Serum & urine immunoglobulin levels and serum beta-2 microglobulin levels help to add a more global aspect to diagnosis and to therapeutic assessment. Any time biopsy of another organ system detects what looks like amyloid (amyloid or para-amyloid), a search begins for a plasma cell dyscrasia [L-06-10703].
  • MGUS:
  • multiple myeloma: must have a "punched out" bone lesion somewhere
  • lymphoplasmacytic lymphoma (Waldenstrom's macoglobulinemia): the macroglobulin can interfere with other...even coagulation ...tests based on reagent antibodies, probably in steric...stoiochemetric...fashion[L-06-10761].

References:

1. Chan, John K. C., MD, Queen Eliz. Hosp., Hong Kong; 111th Semi-annual Seminar of the California Tumor Tissue Registry, 2 Dec. 2001, course syllabus, 183 pages.
2. Am. J. of Gastroenterology 90:946-950, 1995.
3. on-line info & classification
4. Ackerman AB, A Philosophy of Practice of Surgical Pathology: Dermatopathology as a Model, Ardor Scribendi, Ltd., 1999, 470 pages.

(began posting 12 July 2003; addition 12 March 2007)