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|
| MPI and MAI Index |
| |
|
MORPHOMETRIC PROGNOSTIC INDEX (MPI)
and MITOTIC ACTIVITY INDEX (MAI) |
Study #1
survival data on 271 mastectomy patients 1969-1976 (ages 28-86, mean
56)
(all treated by modified radical mastectomy...those with central or medial primaries
or with positive nodes also getting radiation) |
|
Entire group: effect of
MAI |
|
5
year survival |
10
year survival |
| MAI= 0 |
95% |
80% |
| MAI= 4 |
86% |
68% |
| MAI= 16 |
70% |
42% |
| MAI= 36 |
47% |
17% |
| MAI= 81 |
12% |
2.5% |
|
|
Entire group: effect of
MPI |
| |
5 yr survival rate |
9 yr survival rate |
| MPI= -1.0 |
96% |
94% |
| MPI= -0.5 |
94% |
87% |
| MPI= 0 |
90% |
78% |
| MPI= +0.5 |
78% |
66% |
| MPI= +1.0 |
67% |
50% |
| MPI= +1.5 |
50% |
30% |
| MPI= +2.0 |
35% |
13% |
| MPI= +3.0 |
5% |
2% |
|
|
Entire group: effects of
node status and MPI |
| |
5 yr survival rate
|
|
MPI effect:
|
<0.60 |
93% (n=150) |
| >0.60 |
47% (n=121) |
|
node status
effect:
|
ALNN (neg.) |
85% (n=150) |
| ALNP (pos.) |
55% (n=121) |
|
| Conclusion:"Using
two [MPI] thresholds for the probability on dying within 5.5 years,
e. g., 0.40 and 0.60, results in in three categories: 'good' (<0.40), 'uncertain' (0.40-0.60),
and 'bad' (>0.60), with, for example, different therapeutic
approaches. The number of inconclusive ['uncertain'] cases is acceptably
low (16% in this study)." |
Study
#2
Special group of axillary lymph node positive
patients with an improved prognosis (Eastern Cooperative Oncology
Group
Companion Study EST 4189): |
-
368 eligible patients (in a total group of 560)
-
if MAI 0-2 mitoses per 10 40x hpfs, 5 year recurrence
rate only 31%
-
if MAI greater than 2, 5 year recurrence rate is
52%
Reference: David Page, et. al., Vanderbilt U. Dept. Pathology;
J. Clin. Oncol. 18(10):2059-2069; May 2000.
(posted Jan. 2001; latest update 5 August 2002) |
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1999 - 2006, all rights reserved, Pathology Associates Of Lexington,
P.A. |
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