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  EMA BerEP4 CALRETININ Ki67 bcl2 K903 CD34 S100 CEA Vim CK7 CK20 NFP GCDFP-15 HMB45
SCC9 + - -       +* - stroma -*3 -*3 - -5     - -
BCC9 all neg. +     all +   - stroma - - -       - -
morpheic BCC all neg. +     all +   - stroma - -            
desmoplastic trichoepithelioma + -       only basal +   +surrounding epith. islands - -            
microcystic adnexal ca. (MAC) +     <5% + but not diffusely   - stroma3   +            
syringoma + -               +            
Eccrine6 +   +         50% + (-)
+*		 + +(some neg.) -       - -
Sebaceous9 + (multivacuolated)             - +* - ++5     -  
Pilar -4
some say +-		 +           - - -       - -
Apocrine +             - +4 (-) -       Å * -
extra-mammary Paget's +             - ++5   + +      
Merkle1,2,3,4,5,7,8 +             - -   - +
(paranuclear dot)		 + - -
small-cell lung met. to skin +/-             - -   + -/+      
Melanoma -         -   + - Å *   - - - Å
Mixed Tumor + -             +- + - Å (in ME cells & fibroblasts)         -
Met. ca. +-         +-   - + - + -         -
PNET prob. neg.             + - Å *     + - -
* obligatory reaction  1) LMW-ker + with perinuclear glob 2) LCA neg 3) nearly all NSE + and NFP Å 4) usually H&N or extremity location; met. oat usually truncal 5) nuclear detail is diffuse chromatin, whereas ECC or SCC vessic./changed/+ nucleoli 6) rare cases of small-call eccrine can be NSE + and need EM to Dif. Dx. 7) all NSE + 8) usually synapto. & chromogranin neg. 9) seb. strongly Leu M1 pos & SCC, BCC negative 10) CD34 stains dermal dendrocytes 11) all epithelials pankeratin pos. 5/30/07