Disease |
Type of Lesion |
Histology |
DIF |
Fetus |
Prurigo of pregnancy (prurigo gestationis
of Besnier; "early onset prurigo of pregnancy")
(PP) 0.3% of preg. |
Excoriated papules extensor extremities & like
bug bites. |
Nonspecific |
Negative |
Not adverse |
Pruritic folliculitis of pregnancy |
Folliculocentric |
Acute folliculitis |
Negative |
Not adverse |
Papular dermatitis of pregnancy of Spangler
(PDP) (rare) |
Crusted or excoriated 3-5 mm generalized papules
and marked elevation of 24 hr urine HCG |
|
Negative |
Adverse |
Herpes gestationis (HG) (pemphigoid gestationis) |
Papules/vesicles/bullae; sometimes postpartum
onset |
Subepidermal vesicles, teardrop shaped papillary
dermal edema; eosinophiles (H&E highly mimics BP). |
100% of cases linear C3 and/or IgG |
Adverse |
Pruritus gravidarum of atopic women |
|
Atopic changes |
Negative |
Not adverse |
Prurigo gravidarum (intrahepatic cholestasis
of pregnancy [ICP]) |
Jaundice without rash & bile-salt pruritus |
Normal |
Negative |
Adverse |
Impetigo herpetiformis (pustular psoriasis
in pregnancy) |
Minimally pruritic pustules of pustular psoriasis;
may be severely ill. |
Pustules |
Negative |
Adverse |
Pruritic urticarial papules and plaques of
pregnancy (PUPPP); ("toxemic rash of pregnancy of Bourne"; "polymorphic
eruption of pregnancy"; "toxic erythema of pregnancy"; "late
onset prurigo of pregnancy"; "prurigo annularis"' "erythema
multiforme gestationis" |
Usually 3 rd trimester and prim. gravidas;
severely pruritic urticarial papules and plaques & begins
within the abdominal stria ("stretch marks") |
Mixed cells (maybe a few eosinophiles, too) and some pap.
dermal edema but NOT marked; does not vesiculate; focal micro-discrete spongiosis & even
micro-spong. vesicles. |
Negative |
Not adverse |
Autoimmune Progesterone dermatitis |
Nonpruritic, acneiform urticarial |
Eosinophile-rich dermatitis |
Negative |
Not adverse |
Bites |
Pruritic or non-pruritic |
Bite histology |
Negative |
Not adverse |
Dermatitis herpetiformis (DH) |
Pruritic and celiac disease associated and
not specific to pregnancy |
Subepidermal vesiculation and polys and eos.
@ papillary dermal tips |
granular IgA @ papillary dermal BMZ |
|
Linear IgM dermatosis of pregnancy (rare & may
not be a specific dermatosis) |
erythematous follicular papules |
|
linear IgM @ BMZ |
|
